Phenylpropanoids and polyketides
Medchemexpress LLC FK 3311 | 116686-15-8 | MFCD00876455 | 98.7% | C15H13F2NO4S | 50 MG
FK 3311, also known as COX-2 Inhibitor V, is a selective inhibitor of COX-2 with anti-inflammatory properties. It is intended for research use only.
- Targets COX-2
- Exhibits anti-inflammatory activity by inhibiting adjuvant-induced arthritis
- Demonstrates analgesic effects in the acetic acid-induced writhing assay
- Improves L-PVR, CO, PaO(2), and WDR in a canine model of pulmonary ischemia-reperfusion injury
- Reduces histological tissue edema and PMN infiltration
- Lowers serum TxB(2) levels and improves survival rate in pulmonary ischemia-reperfusion injury
- Improves survival rates and lowers serum GOT/GPT levels in liver transplantation with ischemia-reperfusion injury
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Medchemexpress LLC Fk 453 (compound 1d) | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 5 MG
FK 453 (compound 1d) is a potent and selective adenosine A1 receptor antagonist (IC50 17.2 nM) intended for research use. It is a non-xanthine small molecule used in pharmacological studies to probe A1 receptor function and ligand interactions.
- Potent adenosine A1 antagonist (IC50 17.2 nM).
- High purity 99.2%.
- Molecular weight 375.46 g·mol⁻¹.
- Chemical formula C23H25N3O2.
- Supplied as 5 mg solid for laboratory research.
- Suitable for in vitro pharmacology and receptor binding assays.
Medchemexpress LLC N-(1-oxoheptyl)-D-gamma-glutamyl-(6R)-6-carboxy-L-lysyl-D-alanine | 79335-75-4 | 99.9% | 502.57 g/mol | C22H38N4O9 | 25mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 100 MG
Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 100 MG
Medchemexpress LLC LL-37 FK-13 (TFA) | 98.6% | 1719.09 | 10 MG
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13. It functions as an antimicrobial agent that inhibits *Trichomonas vaginalis*. This compound demonstrates minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts.
- TFA salt form of LL-37 FK-13
- Functions as an antimicrobial agent
- Inhibits *Trichomonas vaginalis*
- Demonstrates minimal hemolytic effects on human erythrocytes
- Exhibits low cytotoxicity to human fibroblasts
- Appears as a solid, white to off-white in color
- Soluble in H2O at ≥ 100 mg/mL
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Sigma Aldrich Fine Chemicals Biosciences FK-506 monohydrate >=98% (HPLC) | 109581-93-3 | MFCD11045918 | 5MG
FK-506 monohydrate >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 | 5MG
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 10 MM 1 ML
Tacrolimus monohydrate is a macrocyclic lactone that binds to FKBP to form a complex, inhibiting calcineurin phosphatase. This action suppresses T-lymphocyte signal transduction and IL-2 transcription, resulting in immunosuppressive properties. It is intended for research use only.
- Inhibits T-lymphocyte signal transduction
- Inhibits IL-2 transcription
- Immunosuppressive properties
- Potentiates glucocorticoid and progesterone actions
- May enhance TGFβ-1 gene expression
- Inhibits T cell proliferation
Medchemexpress LLC Tacrolimus (Standard) | 104987-11-3 | 99.6% | 804.02 | 50 MG
Tacrolimus (Standard) is the analytical standard of Tacrolimus, intended for research and analytical applications. It functions as a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which then inhibits T-lymphocyte signal transduction and IL-2 transcription, ultimately possessing immunosuppressive properties. It is suitable for a variety of research assays and experiments.
- Analytical standard grade
- Reference standard for assays
- Used in qualitative, quantitative, and methodological research experiments
- Compatible with techniques such as HPLC, GC, and MS
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | MFCD11045918 | 99.9% | 822.03 g·mol⁻¹ | C44H71NO13 | 5 MG
Tacrolimus monohydrate is a macrocyclic lactone immunosuppressant reagent that binds FK506 binding protein (FKBP) and inhibits calcineurin phosphatase, suppressing T-cell signaling and IL-2 transcription for in vitro immunology and biochemical studies.
- High purity suitable for research applications.
- Molecular formula C44H71NO13; molecular weight 822.03 g·mol⁻¹.
- CAS number 109581-93-3 for unambiguous identification.
- Store protected from light at 4°C; in solution store at -80°C for long-term stability.
- Commonly used in assays targeting calcineurin and FKBP-mediated pathways.